The Synthesis and Evaluation of Aminocoumarin Peptidomimetics as Cytotoxic Agents on Model Bacterial <i>E. coli</i> Strains

The Synthesis and Evaluation of Aminocoumarin Peptidomimetics as Cytotoxic Agents on Model Bacterial <i>E. coli</i> Strains

This work presents the successful synthesis of a library of novel peptidomimetics via Ugi multicomponent reaction. Most of these peptidomimetics contain differently substituted aminocoumarin; 7-amino-4-methylcoumarin and 7-amino-4-(trifluoromethyl) coumarin. Inspired by the biological properties of...

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Bibliographic Details
Main Authors: Paweł Kowalczyk, Monika Wilk, Parul Parul, Mateusz Szymczak, Karol Kramkowski, Stanisława Raj, Grzegorz Skiba, Dorota Sulejczak, Patrycja Kleczkowska, Ryszard Ostaszewski
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Materials
Subjects:
coumarin derivatives
DNA-N-glycosylase
Fpg protein-formamidopyrimidine
lipopolysaccharide (LPS)
oxidative stress
Ugi multicomponent reaction
Online Access:https://www.mdpi.com/1996-1944/14/19/5725

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https://www.mdpi.com/1996-1944/14/19/5725

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