Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood

Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood

Abstract Background DNA methylation biomarkers in circulating cell-free DNA (cfDNA) have great clinical potential for cancer management. Most methods for DNA methylation analysis require bisulfite conversion, causing DNA degradation and loss. This is particularly challenging for cfDNA, which is natu...

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Bibliographic Details
Main Authors: Stine H. Kresse, Sara Brandt-Winge, Heidi Pharo, Bjørnar T. B. Flatin, Marine Jeanmougin, Hege Marie Vedeld, Guro E. Lind
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Clinical Epigenetics
Subjects:
Liquid biopsy
Circulating cell-free tumor DNA
cfDNA
ctDNA
Plasma
cfDNA isolation
Online Access:https://doi.org/10.1186/s13148-023-01563-0

Internet

https://doi.org/10.1186/s13148-023-01563-0

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