Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochrome c levels between mice neural progenitor cells and neurons

Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochrome c levels between mice neural progenitor cells and neurons

Commonly used anesthetic isoflurane has been reported to promote Alzheimer’s disease (AD) neuropathogenesis by inducing caspase-3 activation. However, the up-stream mechanisms of the isoflurane’s effects remain largely to be determined. Specifically, there is a lack of a good model/system to elucida...

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Bibliographic Details
Main Authors: Yiying eZhang, Chuxiong ePan, Xu eWu, Yuanlin eDong, Deborah eCulley, Gregory eCrosby, Tianzuo eLi, Zhongcong eXie
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Anesthesia
Isoflurane
Neurons
Alzheimer’s disease
caspase-3
cytochrome c
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00014/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00014/full

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