Back-Up Base Excision DNA Repair in Human Cells Deficient in the Major AP Endonuclease, APE1

Back-Up Base Excision DNA Repair in Human Cells Deficient in the Major AP Endonuclease, APE1

Apurinic/apyrimidinic (AP) sites are abundant DNA lesions generated both by spontaneous base loss and as intermediates of base excision DNA repair. In human cells, they are normally repaired by an essential AP endonuclease, APE1, encoded by the <i>APEX1</i> gene. Other enzymes can cleave...

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Bibliographic Details
Main Authors: Daria V. Kim, Evgeniia A. Diatlova, Timofey D. Zharkov, Vasily S. Melentyev, Anna V. Yudkina, Anton V. Endutkin, Dmitry O. Zharkov
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
DNA repair
abasic sites
uracil
AP endonucleases
DNA glycosylases
APE1
Online Access:https://www.mdpi.com/1422-0067/25/1/64

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https://www.mdpi.com/1422-0067/25/1/64

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