Hepatic ROS Mediated Macrophage Activation Is Responsible for Irinotecan Induced Liver Injury

Hepatic ROS Mediated Macrophage Activation Is Responsible for Irinotecan Induced Liver Injury

Irinotecan is the first line chemotherapy drug used for treatment of metastatic colorectal cancer worldwide. There is increasing evidence suggesting that liver damage, including steatosis and steatohepatitis, can be caused during the treatment involving irinotecan. However, molecular mechanisms by w...

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Bibliographic Details
Main Authors: Bohao Liu, Cong Ding, Wenbin Tang, Chen Zhang, Yiying Gu, Zhiqiang Wang, Tingzi Yu, Zhuan Li
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
irinotecan
liver injury
chemotherapy
macrophage activation
ROS
Online Access:https://www.mdpi.com/2073-4409/11/23/3791

Internet

https://www.mdpi.com/2073-4409/11/23/3791

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