Persimmon leaf extract alleviates chronic social defeat stress-induced depressive-like behaviors by preventing dendritic spine loss via inhibition of serotonin reuptake in mice

Persimmon leaf extract alleviates chronic social defeat stress-induced depressive-like behaviors by preventing dendritic spine loss via inhibition of serotonin reuptake in mice

Abstract Background Fresh or dried Persimmon leaves (Diospyros kaki Thunb.) exhibit preventive effects on cardiovascular and cerebrovascular diseases. However, their antidepressant effects and underlying mechanisms are unclear. Thus, we investigated mechanisms responsible for Persimmon leaf extract...

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Bibliographic Details
Main Authors: Hui Yu, Shumin Shao, Junnan Xu, Haibiao Guo, Zhangfeng Zhong, Jiangping Xu
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Chinese Medicine
Subjects:
Persimmon leaf
Depression
Serotonin reuptake
Dendritic spines
cAMP/CREB/BDNF signaling pathway
Microbiota–gut–brain axis
Online Access:https://doi.org/10.1186/s13020-022-00609-4

Internet

https://doi.org/10.1186/s13020-022-00609-4

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