Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice

Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice

Abstract Background Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and broke out as a global pandemic in late 2019. The acidic pH environment of endosomes is believed to be essential for SARS-CoV-2 to be able to enter cells and begin replication. However, the clinical use of endosomal a...

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Bibliographic Details
Main Authors: Chao Shang, Xinyu Zhuang, He Zhang, Yiquan Li, Yilong Zhu, Jing Lu, Chenchen Ge, Jianan Cong, Tingyu Li, Mingyao Tian, Ningyi Jin, Xiao Li
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Virology Journal
Subjects:
Endosomal acidification
SARS-CoV-2
Chloroquine
Bafilomycin A1
Online Access:https://doi.org/10.1186/s12985-021-01515-1

Internet

https://doi.org/10.1186/s12985-021-01515-1

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