A lack of GluN2A-containing NMDA receptors confers a vulnerability to redox dysregulation: Consequences on parvalbumin interneurons, and their perineuronal nets

A lack of GluN2A-containing NMDA receptors confers a vulnerability to redox dysregulation: Consequences on parvalbumin interneurons, and their perineuronal nets

The GluN2A subunit of NMDA receptors (NMDARs) plays a critical role during postnatal brain development as its expression increases while Glun2B expression decreases. Mutations and polymorphisms in GRIN2A gene, coding for GluN2A, are linked to developmental brain disorders such as mental retardation,...

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Bibliographic Details
Main Authors: Romain Cardis, Jan-Harry Cabungcal, Daniella Dwir, Kim Q. Do, Pascal Steullet
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Neurobiology of Disease
Subjects:
Oxidative stress
Perineuronal net
Parvalbumin interneuron
Anterior cingulate cortex
Glutahione
Peroxiredoxin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302267

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http://www.sciencedirect.com/science/article/pii/S0969996117302267

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