The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain

The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain

Summary: The composite material-like extracellular matrix (ECM) in the sinoatrial node (SAN) supports the native pacemaking cardiomyocytes (PCMs). To test the roles of SAN ECM in the PCM phenotype and function, we engineered reconstructed-SAN heart tissues (rSANHTs) by recellularizing porcine SAN EC...

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Bibliographic Details
Main Authors: Yao-Hui Sun, Hillary K.J. Kao, Phung N. Thai, Regan Smithers, Che-Wei Chang, Dalyir Pretto, Sergey Yechikov, Sarah Oppenheimer, Amanda Bedolla, Brooke A. Chalker, Rana Ghobashy, Jan A. Nolta, James W. Chan, Nipavan Chiamvimonvat, Deborah K. Lieu
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015176

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http://www.sciencedirect.com/science/article/pii/S2211124723015176

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