A rapid in vitro assay for evaluating the effects of acetylcholinesterase inhibitors and reactivators in the rat basolateral amygdala

A rapid in vitro assay for evaluating the effects of acetylcholinesterase inhibitors and reactivators in the rat basolateral amygdala

We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (OP)-based AChE inhibitor and sarin surrogate 4-nitr...

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Bibliographic Details
Main Authors: Jeffrey S. Thinschmidt, Scott W. Harden, Michael A. King, James D. Talton, Charles J. Frazier
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
organophosphates
basolateral amygdala
acetylcholinesterase
status epilepticus
NIMP
HI-6
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.1066312/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.1066312/full

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