Metabolic Features of Increased Gut Permeability, Inflammation, and Altered Energy Metabolism Distinguish Agricultural Workers at Risk for Mesoamerican Nephropathy

Metabolic Features of Increased Gut Permeability, Inflammation, and Altered Energy Metabolism Distinguish Agricultural Workers at Risk for Mesoamerican Nephropathy

Mesoamerican nephropathy (MeN) is a form of chronic kidney disease found predominantly in young men in Mesoamerica. Strenuous agricultural labor is a consistent risk factor for MeN, but the pathophysiologic mechanism leading to disease is poorly understood. We compared the urine metabolome among men...

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Bibliographic Details
Main Authors: Nathan H. Raines, Dominick A. Leone, Cristina O’Callaghan-Gordo, Oriana Ramirez-Rubio, Juan José Amador, Damaris Lopez Pilarte, Iris S. Delgado, Jessica H. Leibler, Nieves Embade, Rubén Gil-Redondo, Chiara Bruzzone, Maider Bizkarguenaga, Madeleine K. Scammell, Samir M. Parikh, Oscar Millet, Daniel R. Brooks, David J. Friedman
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Metabolites
Subjects:
Mesoamerican nephropathy (MeN)
chronic kidney disease of unknown etiology (CKDu)
chronic kidney disease of nontraditional cause (CKDnt)
nicotinamide adenine dinucleotide (NAD+)
kynurenate
tryptophan
Online Access:https://www.mdpi.com/2218-1989/13/3/325

Internet

https://www.mdpi.com/2218-1989/13/3/325

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