The role of TDP-43 mislocalization in amyotrophic lateral sclerosis

The role of TDP-43 mislocalization in amyotrophic lateral sclerosis

Abstract Since its discovery as a primary component in cytoplasmic aggregates in post-mortem tissue of patients with Amyotrophic Lateral Sclerosis (ALS), TAR DNA Binding Protein 43 kDa (TDP-43) has remained a central focus to understand the disease. TDP-43 links both familial and sporadic forms of A...

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Bibliographic Details
Main Authors: Terry R. Suk, Maxime W. C. Rousseaux
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Molecular Neurodegeneration
Subjects:
ALS
TDP-43
Mislocalization
Pathology
Nucleocytoplasmic shuttling
Online Access:http://link.springer.com/article/10.1186/s13024-020-00397-1

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http://link.springer.com/article/10.1186/s13024-020-00397-1

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