Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes

Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes

Senile plaques composed mainly of β-amyloid (Aβ) and neurofibrillary tangles principally composed of hyperphosphorylated tau are the major pathological features of Alzheimer’s disease (AD). Despite the fact that increased expression of amyloid precursor protein (APP) and presenilin-1 (PS1) transgene...

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Bibliographic Details
Main Authors: M.A Kurt, D.C Davies, M Kidd, K Duff, D.R Howlett
Format: Article
Language:English
Published: Elsevier 2003-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer’s disease
β-Amyloid
Dystrophic neurites
Hyperphosphorylated tau
Neurofibrillary tangles
Paired helical filaments
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103000846

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http://www.sciencedirect.com/science/article/pii/S0969996103000846

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