Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells

Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells

In invertebrate cells, RNA interference (RNAi) acts as a powerful immune defense that stimulates viral gene knockdown thereby preventing infection. With this pathway, virally produced long dsRNA (dsRNA) is cleaved into short interfering RNA (siRNA) by Dicer and loaded into the RNA-induced silencing...

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Bibliographic Details
Main Authors: Shawna L. Semple, Sarah K. W. Au, Rajesh A. Jacob, Karen L. Mossman, Stephanie J. DeWitte-Orr
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
antiviral responses
interferons
long dsRNA
RNAi
viral inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.859749/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.859749/full

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