Site-Selective Incorporation of a Functional Group into Lys175 in the Vicinity of the Active Site of Chymotrypsin by Using Peptidyl α-Aminoalkylphosphonate Diphenyl Ester-Derivatives

Site-Selective Incorporation of a Functional Group into Lys175 in the Vicinity of the Active Site of Chymotrypsin by Using Peptidyl α-Aminoalkylphosphonate Diphenyl Ester-Derivatives

We previously reported that Lys175 in the region of the active site of chymotrypsin (Csin) could be site-selectively modified by using an <i>N</i>-hydroxy succinimide (NHS) ester of the peptidyl derivative containing 1-amino-2-ethylphenylphosphonate diphenyl ester [NHS-Suc-Ala-Ala-Phe<...

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Bibliographic Details
Main Authors: Shin Ono, Masato Koga, Yuya Arimura, Takahiro Hatakeyama, Mai Kobayashi, Jun-ichi Sagara, Takahiko Nakai, Yoshikazu Horino, Hirofumi Kuroda, Hiroshi Oyama, Kazunari Arima
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
chymotrypsin
dansyl group
diphenyl α-aminoalkylphosphonate
site-selective chemical modification
Online Access:https://www.mdpi.com/1420-3049/28/7/3150

Internet

https://www.mdpi.com/1420-3049/28/7/3150

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