The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, sensitizes alveolar and embryonal rhabdomyosarcoma to radiotherapy in vitro and in vivo

The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, sensitizes alveolar and embryonal rhabdomyosarcoma to radiotherapy in vitro and in vivo

Treatment of rhabdomyosarcoma (RMS), the most common a soft tissue sarcoma in childhood, provides intensive multimodal therapy, with radiotherapy (RT) playing a critical role for local tumor control. However, since RMS efficiently activates mechanisms of resistance to therapies, despite improvements...

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Bibliographic Details
Main Authors: Sara Vaccaro, Alessandra Rossetti, Antonella Porrazzo, Simona Camero, Matteo Cassandri, Silvia Pomella, Miriam Tomaciello, Giampiero Macioce, Francesca Pedini, Giovanni Barillari, Cinzia Marchese, Rossella Rota, Giovanni Cenci, Mario Tombolini, Robert A. Newman, Peiying Yang, Silvia Codenotti, Alessandro Fanzani, Francesca Megiorni, Claudio Festuccia, Giuseppe Minniti, Giovanni Luca Gravina, Francesca Vulcano, Luisa Milazzo, Francesco Marampon
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
PBI-05204
oleandrin
rhabdomyosarcoma
Na/K +ATPase
radiotherapy
radiosenisitizing agent
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1071176/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1071176/full

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