Enhanced Anti-Tumor Activity in Mice with Temozolomide-Resistant Human Glioblastoma Cell Line-Derived Xenograft Using SN-38-Incorporated Polymeric Microparticle

Enhanced Anti-Tumor Activity in Mice with Temozolomide-Resistant Human Glioblastoma Cell Line-Derived Xenograft Using SN-38-Incorporated Polymeric Microparticle

Glioblastoma multiforme (GBM) has remained one of the most lethal and <i>challenging</i> cancers to treat. Previous studies have shown encouraging results when irinotecan was used in combination with temozolomide (TMZ) for treating GBM. However, irinotecan has a narrow therapeutic index:...

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Bibliographic Details
Main Authors: Tao-Chieh Yang, Shih-Jung Liu, Wei-Lun Lo, Shu-Mei Chen, Ya-Ling Tang, Yuan-Yun Tseng
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma multiforme (GBM)
SN-38
interstitial chemotherapy
temozolomide-resistance
poly[(d,l)-lactide-co-glycolide] (PLGA)
Online Access:https://www.mdpi.com/1422-0067/22/11/5557

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https://www.mdpi.com/1422-0067/22/11/5557

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