BOK controls ER proteostasis and physiological ER stress responses in neurons

BOK controls ER proteostasis and physiological ER stress responses in neurons

The Bcl-2 family proteins BAK and BAX control the crucial step of pore formation in the mitochondrial outer membrane during intrinsic apoptosis. Bcl-2-related ovarian killer (BOK) is a Bcl-2 family protein with a high sequence similarity to BAK and BAX. However, intrinsic apoptosis can proceed in th...

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Bibliographic Details
Main Authors: Franziska Walter, Beatrice D’Orsi, Anagha Jagannathan, Heiko Dussmann, Jochen H. M. Prehn
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ER stress
Bcl-2 family
unfolded protein response
proteostasis
live-cell imaging
calcium signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.915065/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.915065/full

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