Manufacturing, quality control, and GLP-grade preclinical study of nebulized allogenic adipose mesenchymal stromal cells-derived extracellular vesicles

Manufacturing, quality control, and GLP-grade preclinical study of nebulized allogenic adipose mesenchymal stromal cells-derived extracellular vesicles

Abstract Background Human adipose stromal cells-derived extracellular vesicles (haMSC-EVs) have been shown to alleviate inflammation in acute lung injury (ALI) animal models. However, there are few systemic studies on clinical-grade haMSC-EVs. Our study aimed to investigate the manufacturing, qualit...

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Bibliographic Details
Main Authors: Jing Wang, Zhong-jin Chen, Ze-yi Zhang, Mei-ping Shen, Bo Zhao, Wei Zhang, Ye Zhang, Ji-gang Lei, Cheng-jie Ren, Jing Chang, Cui-li Xu, Meng Li, Yang-yang Pi, Tian-lun Lu, Cheng-xiang Dai, Su-ke Li, Ping Li
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Stem Cell Research & Therapy
Subjects:
Extracellular vesicles
Adipose mesenchymal stromal cells
ALI/ARDS
Inflammation
Online Access:https://doi.org/10.1186/s13287-024-03708-1

Internet

https://doi.org/10.1186/s13287-024-03708-1

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