Prostaglandin EP4 Selective Agonist AKDS001 Enhances New Bone Formation by Minimodeling in a Rat Heterotopic Xenograft Model of Human Bone

Prostaglandin EP4 Selective Agonist AKDS001 Enhances New Bone Formation by Minimodeling in a Rat Heterotopic Xenograft Model of Human Bone

To enhance bone regeneration, the use of bone morphogenetic protein (BMP)-2 is an attractive option. Unfortunately, the dose-dependent side effects prevent its widespread use. Therefore, a novel osteogenic agent using a different mechanism of action than BMP-2 is highly desirable. Previous reports d...

Full description

Bibliographic Details
Main Authors: Yuichiro Ukon, Masahiro Nishida, Natsumi Yamamori, Kazuhiro Takeyama, Kazuhito Sakamoto, Shota Takenaka, Takahiro Makino, Takahito Fujimori, Yusuke Sakai, Yuya Kanie, Joe Kodama, Zeynep Bal, Daisuke Tateiwa, Shinichi Nakagawa, Hiromasa Hirai, Seiji Okada, Takashi Kaito
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
xenograft
EP4 agonist
prostaglandin
bone grafting
autograft
autogenous bone
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.845716/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.845716/full

Similar Items