CD4+ T-cell-dependent differentiation of CD23+ follicular B cells contributes to the pulmonary pathology in a primary Sjögren’s syndrome mouse model

CD4+ T-cell-dependent differentiation of CD23+ follicular B cells contributes to the pulmonary pathology in a primary Sjögren’s syndrome mouse model

IntroductionPrimary Sjögren’s syndrome (pSS) is a systemic autoimmune disease that affects the function of exocrine glands, such as the lacrimal and the salivary glands. Extraglandular lesions and malignant lymphoma also occur during the progressive stage of pSS. We have, herein, focused on the pulm...

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Bibliographic Details
Main Authors: Mami Sato-Fukuba, Rieko Arakaki, Aya Ushio, Kunihiro Otsuka, Ruka Nagao, Shigefumi Matsuzawa, Hiroaki Tawara, Takaaki Tsunematsu, Naozumi Ishimaru
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
primary Sjögren’s syndrome
pulmonary lesion
CD23
follicular B cell
bronchus-associated lymphoid tissue
CD4+ T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1217492/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1217492/full

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