High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast

High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast

Abstract Background p66Shc, as a redox enzyme, regulates reactive oxygen species (ROS) production in mitochondria and autophagy. However, the mechanisms by which p66Shc affects autophagosome formation are not fully understood. Methods p66Shc expression and its location in the trophoblast cells were...

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Bibliographic Details
Main Authors: Lulu Ji, Xiaoli Zhang, Zhiguo Chen, Yuexiao Wang, Hengxuan Zhu, Yaru Nai, Yanyi Huang, Rujie Lai, Yu Zhong, Xiting Yang, Qiongtao Wang, Hanyang Hu, Lin Wang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cell Communication and Signaling
Subjects:
High glucose
p66Shc
Autophagy
cGAS/STING
MAM
Online Access:https://doi.org/10.1186/s12964-024-01621-x

Internet

https://doi.org/10.1186/s12964-024-01621-x

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