PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling

PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling

Cancer cell proliferation and insufficient blood supply can lead to the development of hypoxic areas in the tumor tissue. The adaptation to the hypoxic environment is mediated by a transcriptional complex called hypoxia-inducible factor (HIF). HIF protein levels are tightly controlled by oxygen-depe...

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Bibliographic Details
Main Authors: Antje Egners, Maryam Rezaei, Aleksandar Kuzmanov, David M. Poitz, Doreen Streichert, Thomas Müller-Reichert, Ben Wielockx, Georg Breier
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cancers
Subjects:
prolyl hydroxylase domain protein
PDGF-C
tumor angiogenesis
tumor progression
PDGFR-α
Online Access:https://www.mdpi.com/2072-6694/10/12/496

Internet

https://www.mdpi.com/2072-6694/10/12/496

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