Isothiourea-Catalyzed Enantioselective α-Alkylation of Esters via 1,6-Conjugate Addition to <i>para</i>-Quinone Methides

Isothiourea-Catalyzed Enantioselective α-Alkylation of Esters via 1,6-Conjugate Addition to <i>para</i>-Quinone Methides

The isothiourea-catalyzed enantioselective 1,6-conjugate addition of <i>para</i>-nitrophenyl esters to 2,6-disubstituted <i>para</i>-quinone methides is reported. <i>para</i>-Nitrophenoxide, generated in situ from initial <i>N</i>-acylation of the isot...

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Bibliographic Details
Main Authors: Jude N. Arokianathar, Will C. Hartley, Calum McLaughlin, Mark D. Greenhalgh, Darren Stead, Sean Ng, Alexandra M. Z. Slawin, Andrew D. Smith
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
isothiourea
ammonium enolate
aryloxide
quinone methide
ester functionalization
1,6-conjugate addition
Online Access:https://www.mdpi.com/1420-3049/26/21/6333

Internet

https://www.mdpi.com/1420-3049/26/21/6333

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