Enhanced Oral Bioavailability of Celecoxib Nanocrystalline Solid Dispersion based on Wet Media Milling Technique: Formulation, Optimization and In Vitro/In Vivo Evaluation

Enhanced Oral Bioavailability of Celecoxib Nanocrystalline Solid Dispersion based on Wet Media Milling Technique: Formulation, Optimization and In Vitro/In Vivo Evaluation

Celecoxib (CLX), a selective COX-2 inhibitor, is a biopharmaceutics classification system (BCS) class II drug with its bioavailability being limited by thepoor aqueoussolubility. The purpose of this study was to develop and optimize CLX nanocrystalline(CLX-NC) solid dispersion prepared by the wet me...

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Bibliographic Details
Main Authors: Zhuang Ding, Lili Wang, Yangyang Xing, Yanna Zhao, Zhengping Wang, Jun Han
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Pharmaceutics
Subjects:
nanocrystal
celecoxib
bioavailability
experimental design
wet media milling
lyophilization
Online Access:https://www.mdpi.com/1999-4923/11/7/328

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https://www.mdpi.com/1999-4923/11/7/328

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