Activation of protein kinase C delta following cerebral ischemia leads to release of cytochrome C from the mitochondria via bad pathway.

The release of cytochrome c from the mitochondria following cerebral ischemia is a key event leading to cell death. The goal of the present study was to determine the mechanisms involved in post-ischemic activation of protein kinase c delta (δPKC) that lead to cytochrome c release.We used a rat mode...

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Bibliographic Details
Main Authors: Kunjan R Dave, Sanjoy K Bhattacharya, Isabel Saul, R Anthony DeFazio, Cameron Dezfulian, Hung Wen Lin, Ami P Raval, Miguel A Perez-Pinzon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3137627?pdf=render