STAT3 silencing by an aptamer-based strategy hampers the crosstalk between NSCLC cells and cancer-associated fibroblasts

STAT3 silencing by an aptamer-based strategy hampers the crosstalk between NSCLC cells and cancer-associated fibroblasts

The identification of new effective therapeutic options for non-small-cell lung cancer (NSCLC) represents a crucial challenge in oncology. Recent studies indicate that cancer-associated fibroblasts (CAFs) participate in tumor progression by establishing a favorable microenvironment that promotes can...

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Bibliographic Details
Main Authors: Maria L. Ibba, Giuseppe Ciccone, Deborah Rotoli, Gabriele Coppola, Alfonso Fiorelli, Silvia Catuogno, Carla L. Esposito
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
aptamer
siRNA
chimeras
NSCLC
CAFs
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000562

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http://www.sciencedirect.com/science/article/pii/S2162253123000562

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