Complex CDKL5 translational regulation and its potential role in CDKL5 deficiency disorder

Complex CDKL5 translational regulation and its potential role in CDKL5 deficiency disorder

CDKL5 is a kinase with relevant functions in correct neuronal development and in the shaping of synapses. A decrease in its expression or activity leads to a severe neurodevelopmental condition known as CDKL5 deficiency disorder (CDD). CDD arises from CDKL5 mutations that lie in the coding region of...

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Bibliographic Details
Main Authors: Valeria Ruggiero, Claudio Fagioli, Stefano de Pretis, Valerio Di Carlo, Nicoletta Landsberger, Daniele Zacchetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
CDKL5
translation initiation
5′UTR
CDKL5 deficiency disorder
IRES
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1231493/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1231493/full

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