Dual-Function Semaphorin 4D Released by Platelets: Suppression of Osteoblastogenesis and Promotion of Osteoclastogenesis

Dual-Function Semaphorin 4D Released by Platelets: Suppression of Osteoblastogenesis and Promotion of Osteoclastogenesis

Effects of the antiosteoblastogenesis factor Semaphorin 4D (Sema4D), expressed by thrombin-activated platelets (TPs), on osteoblastogenesis, as well as osteoclastogenesis, were investigated in vitro. Intact platelets released both Sema4D and IGF-1. However, in response to stimulation with thrombin,...

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Bibliographic Details
Main Authors: Satoru Shindo, Irma Josefina Savitri, Takenobu Ishii, Atsushi Ikeda, Roodelyne Pierrelus, Alireza Heidari, Keisuke Okubo, Shin Nakamura, Umadevi Kandalam, Mohamad Rawas-Qalaji, Elizabeth Leon, Maria Rita Pastore, Patrick Hardigan, Toshihisa Kawai
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
platelets
semaphorin 4D
bone regeneration
osteoblasts
osteoclasts
Online Access:https://www.mdpi.com/1422-0067/23/6/2938

Internet

https://www.mdpi.com/1422-0067/23/6/2938

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