MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells

MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells

The MITF transcription factor directly binds to the kinase domain of RAF kinases, including ARAF, BRAF and CRAF in melanoma cells. RAF/MITF complex promotes cytoplasmic accumulation of MITF and thus negatively regulates its transcriptional activity.

Bibliographic Details
Main Authors: Charlène Estrada, Liliana Mirabal-Ortega, Laurence Méry, Florent Dingli, Laetitia Besse, Cedric Messaoudi, Damarys Loew, Celio Pouponnot, Corine Bertolotto, Alain Eychène, Sabine Druillennec
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03049-w

Internet

https://doi.org/10.1038/s42003-022-03049-w

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