Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations

Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations

Background: We recently developed a multi-ancestry polygenic risk score (PRS) that effectively stratifies prostate cancer risk across populations. In this study, we validated the performance of the PRS in the multi-ancestry Million Veteran Program and additional independent studies. Methods: Within...

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Bibliographic Details
Main Authors: Fei Chen, Burcu F Darst, Ravi K Madduri, Alex A Rodriguez, Xin Sheng, Christopher T Rentsch, Caroline Andrews, Wei Tang, Adam S Kibel, Anna Plym, Kelly Cho, Mohamed Jalloh, Serigne Magueye Gueye, Lamine Niang, Olufemi J Ogunbiyi, Olufemi Popoola, Akindele O Adebiyi, Oseremen I Aisuodionoe-Shadrach, Hafees O Ajibola, Mustapha A Jamda, Olabode P Oluwole, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, James E Mensah, Andrew Anthony Adjei, Halimatou Diop, Joseph Lachance, Timothy R Rebbeck, Stefan Ambs, J Michael Gaziano, Amy C Justice, David V Conti, Christopher A Haiman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
polygenic risk scores
prostate cancer
health disparities
African ancestry
Hispanic
multi-ancestry
Online Access:https://elifesciences.org/articles/78304

Internet

https://elifesciences.org/articles/78304

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