Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications

Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications

Metformin is the oldest and most commonly used first-line antidiabetic drug because of its good clinical efficacy, high safety, low cost and easy access. At the same time, in recent years, we have found that its role as a therapeutic drug is gradually expanding. A large number of basic studies have...

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Bibliographic Details
Main Authors: Jin Feng, Xiaohui Wang, Xiaochun Ye, Irma Ares, Bernardo Lopez-Torres, Marta Martínez, María-Rosa Martínez-Larrañaga, Xu Wang, Arturo Anadón, María-Aránzazu Martínez
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Pharmacological Research
Subjects:
Metformin
Antidiabetic drug
Mitochondrial complex I
Oxidative stress
Multiple therapeutic uses
Toxic and side effects
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822000597

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http://www.sciencedirect.com/science/article/pii/S1043661822000597

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