Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children

Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children

Aims/hypothesisAppearance of multiple islet cell autoantibodies in early life is indicative of future progression to overt type 1 diabetes, however, at varying rates. Here, we aimed to study whether distinct metabolic patterns could be identified in rapid progressors (RP, disease manifestation withi...

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Bibliographic Details
Main Authors: Santosh Lamichhane, Partho Sen, Alex M. Dickens, Matilda Kråkström, Jorma Ilonen, Johanna Lempainen, Heikki Hyöty, Riitta Lahesmaa, Riitta Veijola, Jorma Toppari, Tuulia Hyötyläinen, Mikael Knip, Matej Orešič
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Endocrinology
Subjects:
birth cohort
lipidomics
metabolomics
type 1 diabetes mellitus
gut microbial metabolites
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1211015/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1211015/full

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