Acetic Acid as Processing Aid Dramatically Improves Organic Solvent Solubility of Weakly Basic Drugs for Spray Dried Dispersion Manufacture

Acetic Acid as Processing Aid Dramatically Improves Organic Solvent Solubility of Weakly Basic Drugs for Spray Dried Dispersion Manufacture

Many active pharmaceutical ingredients (APIs) in the pharmaceutical pipeline require bioavailability enhancing formulations due to very low aqueous solubility. Although spray dried dispersions (SDDs) have demonstrated broad utility in enhancing the bioavailability of such APIs by trapping them in a...

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Bibliographic Details
Main Authors: Molly S. Adam, Warren K. Miller, Amanda M. Pluntze, Aaron M. Stewart, Jonathan L. Cape, Michael E. Grass, Michael M. Morgen
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
spray drying
pharmaceuticals
poor solubility
processing aid
manufacturability
acetic acid
Online Access:https://www.mdpi.com/1999-4923/14/3/555

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https://www.mdpi.com/1999-4923/14/3/555

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