In vitro and in vivo evaluation of a hydrogel reservoir as a continuous drug delivery system for inner ear treatment.

In vitro and in vivo evaluation of a hydrogel reservoir as a continuous drug delivery system for inner ear treatment.

Fibrous tissue growth and loss of residual hearing after cochlear implantation can be reduced by application of the glucocorticoid dexamethasone-21-phosphate-disodium-salt (DEX). To date, sustained delivery of this agent to the cochlea using a number of pharmaceutical technologies has not been entir...

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Bibliographic Details
Main Authors: Mareike Hütten, Anandhan Dhanasingh, Roland Hessler, Timo Stöver, Karl-Heinz Esser, Martin Möller, Thomas Lenarz, Claude Jolly, Jürgen Groll, Verena Scheper
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4126769?pdf=render

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http://europepmc.org/articles/PMC4126769?pdf=render

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