Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner

Multiple factors such as genes, environment, and age are involved in developing Parkinson’s disease (PD) pathology. However, how various factors interact to cause PD remains unclear. Here, 3-month and 9-month-old hα-syn+⁣/− mice were treated with low-dose rotenone for 2 months to explore the mechani...

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Bibliographic Details
Main Authors: An-Di Chen, Jia-Xin Cao, Hai-Chao Chen, Hong-Li Du, Xiao-Xia Xi, Jing Sun, Jie Yin, Yu-Hong Jing, Li-Ping Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.842380/full