IDH2 Deficiency Is Critical in Myogenesis and Fatty Acid Metabolism in Mice Skeletal Muscle

IDH2 Deficiency Is Critical in Myogenesis and Fatty Acid Metabolism in Mice Skeletal Muscle

Mitochondrial NADP<sup>+</sup>-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate into α-ketoglutarate with concurrent reduction of NADP<sup>+</sup> to NADPH. However, it is not fully understood how IDH2 is intertwined with muscle...

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Bibliographic Details
Main Authors: Jeong Hoon Pan, Jingsi Tang, Young Jun Kim, Jin Hyup Lee, Eui-Cheol Shin, Jiangchao Zhao, Kee-Hong Kim, Kyung A. Hwang, Yan Huang, Jae Kyeom Kim
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
IDH2 knockout
skeletal muscle
myogenesis
mitochondrial biogenesis
fatty acid oxidation
UCP1
Online Access:https://www.mdpi.com/1422-0067/21/16/5596

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https://www.mdpi.com/1422-0067/21/16/5596

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