Tumor endothelial cell-specific drug delivery system using apelin-conjugated liposomes.

BACKGROUND: A drug delivery system specifically targeting endothelial cells (ECs) in tumors is required to prevent normal blood vessels from being damaged by angiogenesis inhibitors. The purpose of this study was to investigate whether apelin, a ligand for APJ expressed in ECs when angiogenesis is t...

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Bibliographic Details
Main Authors: Hiroki Kawahara, Hisamichi Naito, Kazuhiro Takara, Taku Wakabayashi, Hiroyasu Kidoya, Nobuyuki Takakura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3682998?pdf=render