Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice.

Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice.

While non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis combined with inflammation, the mechanisms triggering hepatic inflammation are unknown. In Ldlr(-/-) mice, we have previously shown that lysosomal cholesterol accumulation in Kupffer cells (KCs) correlates with hepatic...

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Main Authors: Tim Hendrikx, Veerle Bieghs, Sofie M A Walenbergh, Patrick J van Gorp, Fons Verheyen, Mike L J Jeurissen, Mandy M F Steinbusch, Nathalie Vaes, Christoph J Binder, Ger H Koek, Rinke Stienstra, Mihai G Netea, Marten H Hofker, Ronit Shiri-Sverdlov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3846469?pdf=render

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http://europepmc.org/articles/PMC3846469?pdf=render

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