The Inhibition of Gastric Cancer Cells’ Progression by 23,24-Dihydrocucurbitacin E through Disruption of the Ras/Raf/ERK/MMP9 Signaling Pathway

The Inhibition of Gastric Cancer Cells’ Progression by 23,24-Dihydrocucurbitacin E through Disruption of the Ras/Raf/ERK/MMP9 Signaling Pathway

Gastric cancer is considered to be one of the most common causes of cancer death worldwide due to its high recurrence and metastasis rates. The molecule 23,24-Dihydrocucurbitacin E (DHCE) is a cucurbitacin-derived tetracyclic triterpenoid compound that has anti-tumor activity, but the exact mechanis...

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Bibliographic Details
Main Authors: Huiping Liu, Huijuan Wang, Aijun Dong, Xiaoshuang Huo, Huaxiang Wang, Junchi Wang, Jianyong Si
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
23,24-Dihydrocucurbitacin E
gastric cancer
ERK2
migration
invasion
Online Access:https://www.mdpi.com/1420-3049/27/9/2697

Internet

https://www.mdpi.com/1420-3049/27/9/2697

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