HIF-1α Expression Increases Preoperative Concurrent Chemoradiotherapy Resistance in Hyperglycemic Rectal Cancer

HIF-1α Expression Increases Preoperative Concurrent Chemoradiotherapy Resistance in Hyperglycemic Rectal Cancer

Purpose: Preoperative concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced rectal cancer patients. However, the poor therapeutic efficacy of CCRT was found in rectal cancer patients with hyperglycemia. This study investigated how hyperglycemia affects radiochemotherapy...

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Bibliographic Details
Main Authors: Yi-Jung Huang, Yi-Ting Chen, Chun-Ming Huang, Shih-Hsun Kuo, Yan-You Liao, Wun-Ya Jhang, Shuo-Hung Wang, Chien-Chih Ke, Yu-Hsiang Huang, Chiu-Min Cheng, Ming-Yii Huang, Chih-Hung Chuang
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
hyperglycemia
HIF-1α
CCRT
rectal cancer
HIF-1α inhibitors
concurrent chemoradiotherapy (CCRT)
Online Access:https://www.mdpi.com/2072-6694/14/16/4053

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https://www.mdpi.com/2072-6694/14/16/4053

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