ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis

ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis

Abstract The transmembrane metalloprotease‐disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors and extracellular matrix components. Here, we report that ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple‐negat...

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Bibliographic Details
Main Authors: Mathilde Romagnoli, Nora D Mineva, Michael Polmear, Catharina Conrad, Srimathi Srinivasan, Delphine Loussouarn, Sophie Barillé‐Nion, Irene Georgakoudi, Áine Dagg, Enda W McDermott, Michael J Duffy, Patricia M. McGowan, Uwe Schlomann, Maddy Parsons, Jörg W Bartsch, Gail E Sonenshein
Format: Article
Language:English
Published: Springer Nature 2013-12-01
Series:EMBO Molecular Medicine
Subjects:
ADAM8
cancer progression
metastasis
therapeutic target
triple‐negative
breast cancer
Online Access:https://doi.org/10.1002/emmm.201303373

Internet

https://doi.org/10.1002/emmm.201303373

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