A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance.

A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance.

The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a 117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a 23-aa (obestatin) mature peptides, which possess biological activities in multi...

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Bibliographic Details
Main Authors: Manuel D Gahete, José Córdoba-Chacón, Marta Hergueta-Redondo, Antonio J Martínez-Fuentes, Rhonda D Kineman, Gema Moreno-Bueno, Raúl M Luque, Justo P Castaño
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3150424?pdf=render

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http://europepmc.org/articles/PMC3150424?pdf=render

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