Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon

Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon

Abstract The oxoglutarate dehydrogenase complex (OGDHc) participates in the tricarboxylic acid cycle and, in a multi-step reaction, decarboxylates α-ketoglutarate, transfers succinyl to CoA, and reduces NAD+. Due to its pivotal role in metabolism, OGDHc enzymatic components have been studied in isol...

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Bibliographic Details
Main Authors: Ioannis Skalidis, Fotis L. Kyrilis, Christian Tüting, Farzad Hamdi, Toni K. Träger, Jaydeep Belapure, Gerd Hause, Marta Fratini, Francis J. O’Reilly, Ingo Heilmann, Juri Rappsilber, Panagiotis L. Kastritis
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04885-0

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https://doi.org/10.1038/s42003-023-04885-0

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