Mesenchymal stem cells, as glioma exosomal immunosuppressive signal multipliers, enhance MDSCs immunosuppressive activity through the miR-21/SP1/DNMT1 positive feedback loop

Mesenchymal stem cells, as glioma exosomal immunosuppressive signal multipliers, enhance MDSCs immunosuppressive activity through the miR-21/SP1/DNMT1 positive feedback loop

Abstract Background The immunosuppressive microenvironment in glioma induces immunotherapy resistance and is associated with poor prognosis. Glioma-associated mesenchymal stem cells (GA-MSCs) play an important role in the formation of the immunosuppressive microenvironment, but the mechanism is stil...

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Bibliographic Details
Main Authors: Wei Qiu, Qindong Guo, Xiaofan Guo, Chaochao Wang, Boyan Li, Yanhua Qi, Shaobo Wang, Rongrong Zhao, Xiao Han, Hao Du, Shulin Zhao, Ziwen Pan, Yang Fan, Qingtong Wang, Zijie Gao, Gang Li, Hao Xue
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Nanobiotechnology
Subjects:
Glioma
Mesenchymal stem cells
Myeloid-derived suppressor cells
Exosomes
miR-21
Anti-PD-1 therapy
Online Access:https://doi.org/10.1186/s12951-023-01997-x

Internet

https://doi.org/10.1186/s12951-023-01997-x

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