The E3 ubiquitin ligase MARCH2 protects against myocardial ischemia-reperfusion injury through inhibiting pyroptosis via negative regulation of PGAM5/MAVS/NLRP3 axis

The E3 ubiquitin ligase MARCH2 protects against myocardial ischemia-reperfusion injury through inhibiting pyroptosis via negative regulation of PGAM5/MAVS/NLRP3 axis

Abstract Inflammasome activation and pyroptotic cell death are known to contribute to the pathogenesis of cardiovascular diseases, such as myocardial ischemia-reperfusion (I/R) injury, although the underlying regulatory mechanisms remain poorly understood. Here we report that expression levels of th...

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Bibliographic Details
Main Authors: Shuolin Liu, Yaguang Bi, Tianting Han, Yiran E. Li, Qihang Wang, Ne Natalie Wu, Chenguo Xu, Junbo Ge, Ronggui Hu, Yingmei Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00622-3

Internet

https://doi.org/10.1038/s41421-023-00622-3

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