Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes

Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes

Abstract Background Human proteins are widely used as drug targets. Integration of large-scale protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus connected genetic variation to disease mechanisms via protein. Previous proteome-by-phenome-wide Mendelian randomizati...

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Bibliographic Details
Main Authors: Chengran Yang, Anne M. Fagan, Richard J. Perrin, Herve Rhinn, Oscar Harari, Carlos Cruchaga
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Genome Medicine
Subjects:
Protein quantitative trait loci
Mendelian randomization
Genetic colocalization
Multi-tissue proteomics
Complex human phenotypes
Online Access:https://doi.org/10.1186/s13073-022-01140-9

Internet

https://doi.org/10.1186/s13073-022-01140-9

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