Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus

Synapse dysfunction and loss are central features of neurodegenerative diseases, caused in part by the accumulation of protein oligomers. Amyloid-β, tau, prion, and α-synuclein oligomers bind to the cellular prion protein (PrPC), resulting in the activation of macromolecular complexes and signaling...

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Main Authors: Daniel Ojeda-Juárez, Jessica A. Lawrence, Katrin Soldau, Donald P. Pizzo, Emily Wheeler, Patricia Aguilar-Calvo, Helen Khuu, Joy Chen, Adela Malik, Gail Funk, Percival Nam, Henry Sanchez, Michael D. Geschwind, Chengbiao Wu, Gene W. Yeo, Xu Chen, Gentry N. Patrick, Christina J. Sigurdson
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Neurobiology of Disease
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Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122002261