Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles

Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles

Abstract The formation of extracellular vesicles (EVs) is induced by the sphingolipid ceramide. How this pathway is regulated is not entirely understood. Here, we report that the ceramide transport protein (CERT) mediates a non‐vesicular transport of ceramide between the endoplasmic reticulum (ER) a...

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Bibliographic Details
Main Authors: Simone M. Crivelli, Caterina Giovagnoni, Zhihui Zhu, Priyanka Tripathi, Ahmed Elsherbini, Zainuddin Quadri, Jian Pu, Liping Zhang, Branislav Ferko, Dusan Berkes, Stefka D. Spassieva, Pilar Martinez‐Martinez, Erhard Bieberich
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Journal of Extracellular Vesicles
Subjects:
AlphaFold2
ceramide
CERT
ER‐endosome contact sites
extracellular vesicles
HPA‐12
Online Access:https://doi.org/10.1002/jev2.12233

Internet

https://doi.org/10.1002/jev2.12233

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