TcpC Inhibits M1 but Promotes M2 Macrophage Polarization via Regulation of the MAPK/NF-κB and Akt/STAT6 Pathways in Urinary Tract Infection

TcpC Inhibits M1 but Promotes M2 Macrophage Polarization via Regulation of the MAPK/NF-κB and Akt/STAT6 Pathways in Urinary Tract Infection

TcpC is a multifunctional virulence factor of Uropathogenic <i>Escherichia coli</i> (UPEC). Macrophages can differentiate into two different subsets M1 and M2 that play distinct roles in anti-infection immunity. Here, we investigate the influence of TcpC on M1/M2 polarization and the pot...

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Bibliographic Details
Main Authors: Jiaqi Fang, Qian Ou, Boheng Wu, Sisi Li, Mian Wu, Jialing Qiu, Nuo Cen, Kaixin Hu, Yangfei Che, Yuan Ma, Jianping Pan
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
UPEC
TcpC
macrophage polarization
MAPK/NF-κB
Akt/STAT
Online Access:https://www.mdpi.com/2073-4409/11/17/2674

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https://www.mdpi.com/2073-4409/11/17/2674

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